1-chloro-3-(trifluoromethyl)benzene derivatives

Fipronil is a broad-spectrum insecticide that belongs to the phenylpyrazole insecticide class. Fipronil disrupts the insect central nervous system by blocking the ligand-gated ion channel of the GABAA receptor (IRAC group 2B) and glutamate-gated chloride (GluCl) channels. This causes hyperexcitation of contaminated insects' nerves and muscles. Fipronil's specificity towards insects is believed to be due to its greater binding affinity for the GABAA receptors of insects than to those of mammals, and for its action on GluCl channels, which do not exist in mammals. , there does not appear to be s

Fluvalinate is a synthetic pyrethroid chemical compound contained as an active agent in the products Apistan, Klartan, and Minadox, that is an acaricide (specifically, a miticide), used to control Varroa mites in honey bee colonies, infestations that constitute a significant disease of such insects.

Afoxolaner is an insecticide and acaricide that belongs to the isoxazoline chemical compound group. It is used to kill fleas and ticks in small animals. ==Mechanism== Alfoxolander is a GABA receptor antagonist, which stops chloride transmission in nerves and muscles resulting in paralysis with the paralysis resulting in death for the insect. Alfoxolaner is more selective for GABA repectors in insects than mammals making it safe to give to an animal in amounts that are still lethal to insects.