1515 establishments in the Spanish Empire

Havana (, ; ) is the capital and largest city of Cuba. The heart of La Habana Province, Havana is the country's main port and commercial center. It is the most populous city, the largest by area, and the second-largest metropolitan area in the Caribbean region. The population in 2021 was inhabitants, and its area is for the capital city and 8,475.57 km2 for the metropolitan zone. Its official population was 1,749,964 inhabitants in 2024.

city and capital of the province of Santiago de Cuba, Cuba

Cumaná () is the capital city of Venezuela's Sucre State. It is located east of Caracas. Cumaná was one of the first cities founded by Spain in the mainland Americas and is the oldest continuously-inhabited Hispanic-established city in South America. Its early history includes several successful counters by the indigenous people of the area who were attempting to prevent Spanish incursion into their land, resulting in the city being refounded several times. The municipality of Sucre, which includes the capital city, Cumaná, had a population of 358,919 at the 2011 Census; the latest estimate (a

human settlement

Acla was a Spanish colonial town founded by order of the Governor of Castilla de Oro, Pedrarias Dávila, in 1515. It was located on the central coastline of the modern-day Guna Yala, to the northeast of Panama. The town's name means bones of men in the indigenous language. The name comes from the large number of bones strewn about the nearby plains, which supposedly came from the conflicts between two indigenous brothers who fought to become chiefs of the region.