Louisville Muhammad Ali International Airport

airport in Louisville, Kentucky, United States

cargo airline in the United States

UPS Airlines Flight 2976 was a scheduled domestic cargo flight in the United States from Louisville Muhammad Ali International Airport in Louisville, Kentucky, to Honolulu, Hawaii. On November 4, 2025, the McDonnell Douglas MD-11 operating the flight suffered a separation of its left engine during its takeoff roll and crashed into an industrial area seconds after liftoff from the runway, at about 5:13 p.m. local time (22:13 UTC). The crash killed all three crew members on board the aircraft, and an additional twelve people on the ground, one of whom succumbed to their injuries on December 25.