Urban districts of Hesse

Frankfurt am Main, usually shortened to Frankfurt, is the most populous city in the German state of Hesse. Its 778,589 inhabitants as of 2025 make it the fifth-most populous city in Germany. Located in the foreland of the Taunus on its namesake Main, the city forms a continuous conurbation with Offenbach am Main; its urban area has a population of over 2.7 million. Frankfurt is the heart of the larger Rhine-Main metropolitan region, which has a population of more than 5.8 million and is Germany's second-largest metropolitan region after the Rhine-Ruhr region. Home to the European Central Bank,

Wiesbaden (; ) is the capital of the German state of Hesse, and the second-largest Hessian city after Frankfurt am Main. With around 283,000 inhabitants, it is Germany's 24th-largest city. Wiesbaden forms a conurbation with a population of around 500,000 with the neighbouring city of Mainz. This conurbation is in turn embedded in the Rhine-Main Metropolitan Region—Germany's second-largest metropolitan region after Rhine-Ruhr—which also includes the nearby cities of Frankfurt am Main, Darmstadt, Offenbach am Main, and Hanau, and has a combined population exceeding 5.8 million.

thumb|Landmark of Darmstadt: ("Wedding Tower"), built in 1908 in Art Nouveau|Jugendstil architecture at Mathildenhöhe Darmstadt ( , , , ) is a city in the state of Hesse in Germany, located in the southern part of the Rhine-Main-Area (Frankfurt Metropolitan Region). Darmstadt has around 160,000 inhabitants, making it the fourth largest city in the state of Hesse after Frankfurt am Main, Wiesbaden, and Kassel.

Kassel (; in Germany, spelled Cassel until 1926) is a city on the Fulda River in northern Hesse, in central Germany. It is the administrative seat of the Regierungsbezirk Kassel and the district of the same name, and had 201,048 inhabitants in December 2020. The former capital of the state of Hesse-Kassel, it has many palaces and parks, including the Bergpark Wilhelmshöhe, which is a UNESCO World Heritage Site. Kassel is also known for the documenta exhibitions of contemporary art. Kassel has a public university with 25,000 students (2018) and a multicultural population (39% of the citizens in

city in Hesse, Germany