Cardiac glycosides

class of organic compounds that increase the output force of the heart and decrease its rate of contractions by acting on the cellular sodium-potassium ATPase pump

Oleandrin is a cardiac glycoside found in the poisonous plant oleander (Nerium oleander L.). As a main phytochemical of oleander, oleandrin is associated with the toxicity of oleander sap, and has similar properties to digoxin. Oleandrin and other oleander chemicals are potentially toxic to the heart, liver, and kidneys.

Antiarins are cardiac glycoside poisons produced by the upas tree (Antiaris toxicaria). There are two closely related forms, α-antiarin and β-antiarin. The two share the same aglycone, antiarigenin, but differ in the sugar group that is attached to it.

Cerberin is a type of cardiac glycoside found in the seeds of trees in the genus Cerbera, including the suicide tree (Cerbera odollam) and the sea mango (Cerbera manghas). As a cardiac glycoside, cerberin disrupts the function of the heart by blocking its sodium and potassium ATPase. Cerberin can be used as a treatment for heart failure and arrhythmia.