2-aminopyridine
Also known as α-Aminopyridine, α-Pyridylamine, alpha-aminopyridine, alpha-pyridylamine, 2-Pyridylamine, alpha-Pyridinamine, Amino-2 pyridine
2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.
Research
804 papers- 2-Aminopyridine - an unsung hero in drug discovery.Chemical communications (Cambridge, England) · 2022
- Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation.Molecules (Basel, Switzerland) · 2024
- 2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.International journal of molecular sciences · 2020
- Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies.Molecules (Basel, Switzerland) · 2022
- Cellular uptake of 2-aminopyridine-modified peptide nucleic acids conjugated with cell-penetrating peptides.Biopolymers · 2022
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Article
4 sectionsContents
- Reactions
- Toxicity
- References
- External links
2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.
==Reactions== thumb|The bifunctionality of 2-aminopyridine is illustrated by this 1:2 adduct with maleic anhydride.|left|110px Although 2-hydroxypyridine converts significantly to the pyridone tautomer, the related imine tautomer (HNC5H4NH) is less important for 2-aminopyridine.