2-aminopyridine

Also known as α-Aminopyridine, α-Pyridylamine, alpha-aminopyridine, alpha-pyridylamine, 2-Pyridylamine, alpha-Pyridinamine, Amino-2 pyridine

2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.

Research

804 papers

2-Aminopyridine - an unsung hero in drug discovery.Chemical communications (Cambridge, England) · 2022
Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation.Molecules (Basel, Switzerland) · 2024
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.International journal of molecular sciences · 2020
Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies.Molecules (Basel, Switzerland) · 2022
Cellular uptake of 2-aminopyridine-modified peptide nucleic acids conjugated with cell-penetrating peptides.Biopolymers · 2022

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Encyclopedic overview

4 sections

Contents

Reactions
Toxicity
References
External links

==Reactions== thumb|The bifunctionality of 2-aminopyridine is illustrated by this 1:2 adduct with maleic anhydride.|left|110px Although 2-hydroxypyridine converts significantly to the pyridone tautomer, the related imine tautomer (HNC5H4NH) is less important for 2-aminopyridine.

Excerpted from Wikipedia’s “2-aminopyridine” article, available under the CC BY-SA 4.0 licence.