2-aminopyridine
Sign in to saveAlso known as α-Aminopyridine, α-Pyridylamine, alpha-aminopyridine, alpha-pyridylamine, 2-Pyridylamine, alpha-Pyridinamine, Amino-2 pyridine
2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.
Research
804 papers- 2-Aminopyridine - an unsung hero in drug discovery.Chemical communications (Cambridge, England) · 2022
- Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation.Molecules (Basel, Switzerland) · 2024
- 2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.International journal of molecular sciences · 2020
- Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies.Molecules (Basel, Switzerland) · 2022
- Cellular uptake of 2-aminopyridine-modified peptide nucleic acids conjugated with cell-penetrating peptides.Biopolymers · 2022
via PubMed
Wikidata facts
- Subclass of
- pyridine alkaloid
- Mass
- 95.10
Show 16 more facts
- chemical formula
- C₄H₅N₃
- median lethal dose (LD50)
- 70
- NIOSH Pocket Guide ID
- 0026
- immediately dangerous to life or health
- 19.25
- solubility
- 100
- melting point
- 137
- boiling point
- 411
- vapor pressure
- 0.8
- flash point
- 154
- ionization energy
- 8
- time-weighted average exposure limit
- 0.5
- minimal lethal dose
- 50
- short-term exposure limit
- 2
- canonical SMILES
- C1=CC=NC(=C1)N
- subject has role
- fluorophore
- Commons category
- 2-Aminopyridine
via Wikidata · CC0
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Encyclopedic overview
4 sectionsContents
- Reactions
- Toxicity
- References
- External links
2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.
==Reactions== thumb|The bifunctionality of 2-aminopyridine is illustrated by this 1:2 adduct with maleic anhydride.|left|110px Although 2-hydroxypyridine converts significantly to the pyridone tautomer, the related imine tautomer (HNC5H4NH) is less important for 2-aminopyridine.
Excerpted from Wikipedia’s “2-aminopyridine” article, available under the CC BY-SA 4.0 licence.