Skip to content
2-imidazoline
EntityQ419555· pop 17· linked from 11 articles

2-imidazoline

Sign in to save

Also known as 4,5-Dihydro-1H-imidazole, I2, I2-imidazoline

2-Imidazoline (Preferred IUPAC name: '4,5-dihydro-1H-imidazole') is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula C3H6N2. The 2-imidazolines are the most common imidazolines commercially, as the ring exists in some natural products and some pharmaceuticals. They also have been examined in the context of organic synthesis, coordination chemistry, and homogeneous catalysis.

~3 min read

Encyclopedic overview

11 sections
Contents
  • Synthesis
  • As natural products
  • Biological role
  • Applications
  • Pharmaceutical
  • As p53 activators
  • Surfactants
  • As precursors of imidazoles
  • Homogeneous catalysis
  • See also
  • References

2-Imidazoline (Preferred IUPAC name: '4,5-dihydro-1H-imidazole') is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula C3H6N2. The 2-imidazolines are the most common imidazolines commercially, as the ring exists in some natural products and some pharmaceuticals. They also have been examined in the context of organic synthesis, coordination chemistry, and homogeneous catalysis.

== Synthesis == thumb|left|400px|Synthesis of imidazolines from nitrile and from ester precursors. A variety of routes exist for the synthesis of imidazolines, with the most common methods involving the condensation of 1,2-diamines (e.g. ethylenediamine) with nitriles or esters. The nitrile based route is essentially a cyclic Pinner reaction; it requires high temperatures and acid catalysis and is effective for both alkyl and aryl nitriles.

Excerpted from Wikipedia’s “2-imidazoline” article, available under the CC BY-SA 4.0 licence.

Gallery (2)