ADME
Sign in to saveAlso known as LADME, ADMET, LADMET, drug ADME, absorption, distribution, metabolism, excretion, liberation, absorption, distribution, metabolism, excretion
thumb|Processes in pharmacokinetics ADME is the four-letter abbreviation (acronym) for absorption, distribution, metabolism, and excretion, and is mainly used in fields such as pharmacokinetics and pharmacology. The four letters stand for descriptors quantifying how a given drug interacts within body over time. The term ADME was first introduced in the 1960s, and has become a standard term widely used in scientific literature, teaching, drug regulations, and clinical practice.
~5 min read
Article
8 sectionsContents
- Components
- Absorption/administration
- Distribution
- Metabolism
- Excretion
- Toxicity
- See also
- References
thumb|Processes in pharmacokinetics ADME is the four-letter abbreviation (acronym) for absorption, distribution, metabolism, and excretion, and is mainly used in fields such as pharmacokinetics and pharmacology. The four letters stand for descriptors quantifying how a given drug interacts within body over time. The term ADME was first introduced in the 1960s, and has become a standard term widely used in scientific literature, teaching, drug regulations, and clinical practice.
ADME describes the disposition of a pharmaceutical compound within an organism. The four criteria all influence the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug. Sometimes liberation and/or toxicity are also considered, yielding LADME, ADMET, or LADMET.