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EntityQ413888· pop 14· linked from 16 articles

Also known as Aloin, barbaloin

Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound noted in the exudate of at least 68 Aloe species at levels from 0.1 to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 species at indeterminate levels [Reynolds, 1995b]. It is used as a stimulant-laxative, treating constipation by inducing bowel movements. The compound is present in what is commonly referred to as the aloe latex that exudes from cells adjacent to the vascular bundles, found under the rind of the leaf and in between it and the gel.

Key facts

Drug.Verifiedfields
changed
Drug.Watchedfields
changed
Drug.verifiedrevid
477318559
Drug.IUPAC_name
Aloin A: (10S)-10-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone
Drug.image
Aloin structure.png
Drug.image_class
skin-invert-image
Drug.image2
Aloin.jpg
Drug.routes_of_administration
Oral
Drug.CAS_number
8015-61-0
Drug.ATC_prefix
none
Drug.PubChem
313325
Drug.ChemSpiderID
24534069
Drug.ChEBI
73222
Drug.ChEMBL
497001
Drug.UNII
W41H6S09F4
Drug.KEGG
C10305
Drug.C
21
Drug.H
22

via Wikipedia infobox

~5 min read

Encyclopedic overview

5 sections
Contents
  • Structure and preparation
  • Effects
  • Legal status
  • References
  • External links

Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound noted in the exudate of at least 68 Aloe species at levels from 0.1 to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 species at indeterminate levels [Reynolds, 1995b]. It is used as a stimulant-laxative, treating constipation by inducing bowel movements. The compound is present in what is commonly referred to as the aloe latex that exudes from cells adjacent to the vascular bundles, found under the rind of the leaf and in between it and the gel.

When dried, it has been used as a bittering agent in commerce (alcoholic beverages) [21 CFR 172.510. Scientific names given include Aloe perryi, A. barbadensis (= A. vera), A. ferox, and hybrids of A. ferox with A. africana and A. spicata.]. Aloe is listed in federal regulations as a natural substance that may be "safely used in food" when used "in the minimum quantity required to produce their intended physical or technical effect and in accordance with all the principles of good manufacturing practice." This food application is generally limited to use in quite small quantities as a flavoring in alcoholic beverages and may usually be identified only as a "natural flavor."

Excerpted from Wikipedia’s “aloin A” article, available under the CC BY-SA 4.0 licence.