alovudine

Also known as MIV-310, 3'-Fluoro-3'-deoxythymidine

Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.

In the Vinony graph

Vinony's link graph records 6 inbound references to alovudine, and connects out to tenofovir alafenamide, nucleoside analogue and medication.

Vinony files it under Abandoned drugs, Antiviral drugs and Chemical pages without DrugBank identifier.

Vinony links it to 4 Wikipedia language editions.

Chemical data

Formula: C10H13FN2O4
Molecular weight: 244.22 g/mol
IUPAC name: 1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)F
InChIKey: UXCAQJAQSWSNPQ-XLPZGREQSA-N
XLogP: -0.3
Polar surface area: 78.9 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: HIV infection

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 244.086

Show 4 more facts

Commons category: Alovudine
chemical formula: C₁₀H₁₃FN₂O₄
canonical SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F
isomeric SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)F

Sources (2)

via Wikidata · CC0

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Encyclopedic overview

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Contents

See also
References

Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.

== See also == Fluorothymidine F-18, an isotopically enriched version of alovudine used as a PET tracer

Excerpted from Wikipedia’s “alovudine” article, available under the CC BY-SA 4.0 licence.