amixetrine
Sign in to saveAmixetrine (INN; brand name Somagest; developmental code CERM-898) is a drug that was formerly marketed in France but is now no longer sold. According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic, but its definitive indications and pharmacology are unclear. The drug was first synthesized in 1969 and was introduced in France in 1972.
In the Vinony graph
Vinony's link graph records 5 inbound references to amixetrine, and connects out to France, International Standard Book Number and drug.
Vinony files it under 1-Pyrrolidinyl compounds, Abandoned drugs and Antidepressants.
Vinony links it to 4 Wikipedia language editions.
Wikidata facts
- Mass
- 261.209
Show 3 more facts
- chemical formula
- C₁₇H₂₇NO
- canonical SMILES
- CC(C)CCOC(CN1CCCC1)C2=CC=CC=C2
- Commons category
- Amixetrine
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Amixetrine (INN; brand name Somagest; developmental code CERM-898) is a drug that was formerly marketed in France but is now no longer sold. According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic, but its definitive indications and pharmacology are unclear. The drug was first synthesized in 1969 and was introduced in France in 1972.
==Synthesis== The treatment of isoamyl alcohol (1) with styrene (2) at −10 °C with dropwise addition of tert-butyl hypobromite gives (2-bromo-1-(isopentyloxy)ethyl)benzene (3). Displacement of the halogen leaving group by pyrrolidine completes the synthesis of amixetrine (4).
Excerpted from Wikipedia’s “amixetrine” article, available under the CC BY-SA 4.0 licence.