Structure via PubChem · Public domain (PubChem)
anthralin
Sign in to saveAlso known as Dithranol
Dithranol (INN) or anthralin (USAN and former BAN) is a hydroxyanthrone, anthracene derivative, and is used in medications applied to the skin of people with psoriasis. It is available as creams, ointment or pastes in 0.1 to 2% strengths (Drithocreme, Dithrocream, Zithranol-RR, Micanol, Psorlin, Dritho-Scalp, Anthraforte, Anthranol and Anthrascalp). The terms dithranol and anthralin are sometimes used synonymously.
Chemical data
- Formula
- C14H10O3
- Molecular weight
- 226.23 g/mol
- IUPAC name
- 1,8-dihydroxy-10H-anthracen-9-one
- SMILES
- C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O
- InChIKey
- NUZWLKWWNNJHPT-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 57.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
1,378 papersvia PubMed
Wikidata facts
- Mass
- 226.062994
Show 4 more facts
- chemical formula
- C₁₄H₁₀O₃
- canonical SMILES
- C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O
- melting point
- 179
- Commons category
- Dithranol
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- References
- Further reading
Dithranol (INN) or anthralin (USAN and former BAN) is a hydroxyanthrone, anthracene derivative, and is used in medications applied to the skin of people with psoriasis. It is available as creams, ointment or pastes in 0.1 to 2% strengths (Drithocreme, Dithrocream, Zithranol-RR, Micanol, Psorlin, Dritho-Scalp, Anthraforte, Anthranol and Anthrascalp). The terms dithranol and anthralin are sometimes used synonymously.
==Medical uses== Dithranol has a slower onset of action in controlling psoriasis, typically several weeks, compared to glucocorticoid steroids, but is without the potential for rebound reaction on withdrawal. It cannot be used on the face or genitalia. There is some tentative evidence that anthralin might be useful for alopecia areata.