APOBEC3B

Also known as A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2, apolipoprotein B mRNA editing enzyme catalytic subunit 3B

Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene.

Gene data

APOBEC3B

Name: apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Type: protein-coding
Position: 38,982,347–38,992,804 (+)
Aliases: A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2
Ensembl: ENSG00000179750
RefSeq RNA: NM_001270411.2, NM_004900.5
RefSeq protein: NP_001257340.2, NP_004891.5

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].

Pathways

Human immunodeficiency virus 1 infection - Homo sapiens (human)mRNA Editing: C to U Conversion mRNA Editing Formation of the Editosome Metabolism of RNA

via MyGene.info

Gene · Ensembl

apolipoprotein B mRNA editing enzyme catalytic subunit 3B

Symbol: APOBEC3B
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:38,982,347-38,992,804
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 105420
exact match: identifiers.org/ncbigene/9582
genomic start: 39378352
genomic end: 39388809
cytogenetic location: 22q13.1

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Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene.

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and APOBEC3B proteins can cause specific mutations in cancer genomes called APOBEC mutagenesis and several factors including genetic and environmental influence this mutation pattern among patients specifically in bladder and breast cancer. This gene is also overexpressed in multiple myeloma, possibly aiding its formation.