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binedaline
Sign in to saveAlso known as binodaline, Ixprim
Binedaline (also called binodaline or binedaline hydrochloride) is a drug that was investigated as an antidepressant in the 1980s but was never marketed. It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 μM) transporters. It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.
Chemical data
- Formula
- C19H23N3
- Molecular weight
- 293.4 g/mol
- IUPAC name
- N,N,N'-trimethyl-N'-(3-phenylindol-1-yl)ethane-1,2-diamine
- SMILES
- CN(C)CCN(C)N1C=C(C2=CC=CC=C21)C3=CC=CC=C3
- InChIKey
- SXYFFMXPDDGOEK-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 11.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 293.18919773600004
Show 3 more facts
- canonical SMILES
- CN(C)CCN(C)N1C=C(C2=CC=CC=C21)C3=CC=CC=C3
- chemical formula
- C₁₉H₂₃N₃
- Commons category
- Binedaline
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Binedaline (also called binodaline or binedaline hydrochloride) is a drug that was investigated as an antidepressant in the 1980s but was never marketed. It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 μM) transporters. It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.
==Synthesis== [[File:Binedaline synthesis.svg|thumb|center|500px|class=skin-invert-image|Thieme Synthesis: Patents:]]
Excerpted from Wikipedia’s “binedaline” article, available under the CC BY-SA 4.0 licence.