bryostatin
Sign in to saveAlso known as bryostatins
Bryostatins are a group of macrolide lactones from (bacterial symbionts of) the marine organism Bugula neritina that were first collected and provided to JL Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe. Bryostatins are potent modulators of protein kinase C. They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer's disease.
Research
1,008 papers- Bryostatin-1: a novel PKC inhibitor in clinical development.Cancer investigation · 2003
- Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.CNS drug reviews · 2006
- Bryostatin-1 Decreases HIV-1 Infection and Viral Production in Human Primary Macrophages.Journal of virology · 2022
- Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11.Frontiers in immunology · 2024
- Bryostatin-1 alleviates experimental multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2018
via PubMed
~4 min read
Encyclopedic overview
6 sectionsContents
- Biological effects
- Chemistry
- Biosynthesis
- References
- Further reading
- External links
Bryostatins are a group of macrolide lactones from (bacterial symbionts of) the marine organism Bugula neritina that were first collected and provided to JL Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe. Bryostatins are potent modulators of protein kinase C. They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer's disease.
== Biological effects ==
Excerpted from Wikipedia’s “bryostatin” article, available under the CC BY-SA 4.0 licence.