Structure via PubChem · Public domain (PubChem)
calcium gluconate
Sign in to saveAlso known as Calcarea gluconica, Calcii gluconas, Calcium gluconate anhydrous, Calcium gluconate, anhydrous, D-gluconic acid, calcium salt (2:1), Calcium di-gluconate, E578
chemical compound
Key facts
- Pronunciation
- KAL -see-um GLUE -koe-nate
- Ahfs drugs com
- Monograph
- License data
- United States</span>"}]]}'>US DailyMed : Calcium gluconate
- Routes of administration
- By mouth , intravenous , topical
- Atc code
- A12AA03 ( WHO ) (Oral), D11AX03 ( WHO ), B05XA19 ( WHO ) (Parenteral)
- Cas number
- 299-28-5
- Drugbank
- DB11126
- Unii
- SQE6VB453K
- Kegg
- D00935
- Chebi
- CHEBI:3309
- Chembl
- ChEMBL2106119
- E number
- E578 (acidity regulators, ...)
- Comptox dashboard u s environmental prot
- DTXSID2029618
- Echa infocard
- 100.005.524
- Formula
- C 12 H 22 Ca O 14
- Molar mass
- 430.372 g·mol
- 3d model jsmol
- Interactive image
- Melting point
- 120 °C (248 °F) (decomposes)
via Wikipedia infobox
Chemical data
- Formula
- C12H22CaO14
- Molecular weight
- 430.37 g/mol
- IUPAC name
- calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
- SMILES
- C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Ca+2]
- InChIKey
- NEEHYRZPVYRGPP-IYEMJOQQSA-L
- Polar surface area
- 283 Ų
- H-bond donors
- 10
- H-bond acceptors
- 14
- Formal charge
- 0
via PubChem
Research
2,930 papers- Calcium gluconate infusion is not as effective as dopamine agonists in preventing ovarian hyperstimulation syndrome.European review for medical and pharmacological sciences · 2022
- Lesions Associated With Calcium Gluconate Extravasation: Presentation of 5 Clinical Cases and Analysis of Cases Published.Annals of plastic surgery · 2017
- Effect of prophylactic intravenous calcium gluconate on uterine atony during intrapartum cesarean delivery with spinal anesthesia: a placebo controlled, randomized clinical trial.International journal of obstetric anesthesia · 2025
- Calcium gluconate pretreatment for prevention of succinylcholine-induced myalgia.Anesthesia and analgesia · 1983
- Solving the calcium gluconate shortage in real-time: Mistakes made and lessons learned.Journal of clinical apheresis · 2019
via PubMed
~6 min read
Encyclopedic overview
Calcium gluconate is the calcium salt of gluconic acid and is used as a mineral supplement and medication. As a medication it is used by injection into a vein to treat low blood calcium, high blood potassium, and magnesium toxicity. Supplementation is generally only required when there is not enough calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets. It can also be taken by mouth but is not recommended for injection into a muscle.
Side effects when injected include slow heart rate, pain at the site of injection, and low blood pressure. When taken by mouth side effects may include constipation and nausea. Blood calcium levels should be measured when used and extra care should be taken in those with a history of kidney stones. At normal doses, use is regarded as safe in pregnancy and breastfeeding. Calcium gluconate is made by mixing gluconic acid with calcium carbonate or calcium hydroxide.
Excerpted from Wikipedia’s “calcium gluconate” article, available under the CC BY-SA 4.0 licence.