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EntityQ15410917· pop 5· linked from 4 articles

CPhos is a phosphine ligand derived from biphenyl. It is a white solid that is soluble in organic solvents.

Wikidata facts

Mass
436.3007359420001
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canonical SMILES
CN(C)C1=C(C(=CC=C1)N(C)C)C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4
chemical formula
C₂₈H₄₁N₂P
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4 sections
Contents
  • Utility in Negishi Coupling
  • See also
  • References
  • External links

CPhos is a phosphine ligand derived from biphenyl. It is a white solid that is soluble in organic solvents.

Its palladium complexes exhibit high activity for Negishi coupling reactions involving aryl bromides, chlorides and triflates. CPhos mediated reactions performed with secondary (sp3) alkylzinc halides often give excellent yields, with low conversion to the frequently encountered primary substituted by-products.

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