DDX27
Sign in to saveAlso known as DRS1, Drs1p, PP3241, RHLP, dJ686N3.1, HSPC259, DEAD-box helicase 27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.
Gene data
DDX27- Name
- DEAD-box helicase 27
- Type
- protein-coding
- Position
- 49,219,347–49,244,077 (+)
- Aliases
- DRS1, Drs1p, HSPC259, PP3241, RHLP, dJ686N3.1
- Ensembl
- ENSG00000124228
- RefSeq RNA
- NM_001348187.2, NM_017895.8
- RefSeq protein
- NP_001335116.2, NP_060365.8
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
DEAD-box helicase 27
- Symbol
- DDX27
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:49,219,347-49,244,077
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.
The protein encoded by this gene belongs to the family of DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined.
Excerpted from Wikipedia’s “DDX27” article, available under the CC BY-SA 4.0 licence.