Structure via PubChem · Public domain (PubChem)
delavirdine
Sign in to saveAlso known as U-90152, Rescriptor, (N-[2-[4-[3-(1-Methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide), 1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine, N-(2-(1-(3-(Isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide, N-{2-[4-(3-isopropylamino-pyridin-2-yl)-piperazine-1-carbonyl]-1H-indol-5-yl}-methanesulfonamide, 2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine, Delavirdin
Delavirdine (DLV) (brand name Rescriptor) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that was marketed by ViiV Healthcare. It was used as part of highly active antiretroviral therapy (HAART) for the treatment of HIV-1 in the late 1990s and early 2000s. It is presented as the mesylate. The recommended dosage is 400 mg (as four 100-mg tablets or two 200-mg tablets) three times a day.
Chemical data
- Formula
- C22H28N6O3S
- Molecular weight
- 456.6 g/mol
- IUPAC name
- N-[2-[4-[3-(propan-2-ylamino)-2-pyridinyl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide
- SMILES
- CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C
- InChIKey
- WHBIGIKBNXZKFE-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 119 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
~4 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- Adverse effects
- Synthesis
- References
{{Drugbox | verifiedrevid = 460774806 | image = Delavirdine.svg | image_class = skin-invert-image | image2 = Delavirdine ball-and-stick model.png | image_class2 = bg-transparent | width = 250
| tradename = Rescriptor | Drugs.com = | MedlinePlus = a600034 | pregnancy_AU = B3 | routes_of_administration = By mouth | ATC_prefix = J05 | ATC_suffix = AG02 | ATC_supplemental =
Excerpted from Wikipedia’s “delavirdine” article, available under the CC BY-SA 4.0 licence.