DGKA
Sign in to saveAlso known as DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.
Gene data
DGKA- Name
- diacylglycerol kinase alpha
- Type
- protein-coding
- Position
- 55,927,319–55,954,027 (+)
- Aliases
- DAGK, DAGK1, DGK-alpha
- Ensembl
- ENSG00000065357
- RefSeq RNA
- NM_001345.5, NM_001351033.2, NM_001351034.2, NM_001351035.1, NM_001351036.2
- RefSeq protein
- NP_001336.2, NP_001337962.1, NP_001337963.1, NP_001337964.1, NP_001337965.1
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
diacylglycerol kinase alpha
- Symbol
- DGKA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:55,927,319-55,954,027
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DGKA PDB 1tuz.png
Show 5 more facts
- HomoloGene ID
- 1028
- exact match
- identifiers.org/ncbigene/1606
- genomic start
- 56321103
- genomic end
- 56347811
- cytogenetic location
- 12q13.2
Sources (3)
via Wikidata · CC0
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Article
3 sectionsContents
- References
- Further reading
- External links
Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.