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diphencyprone

Structure via PubChem · Public domain (PubChem)

EntityQ5279743· pop 10· linked from 8 articles

diphencyprone

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Also known as DPCP, DPC, 2,3-Diphenylcycloprop-2-en-1-one, 2,3-Diphenylcyclopropenone, Diphenylcyclopropenone

Diphenylcyclopropenone (diphencyprone) is a topically administered experimental drug intended for treating alopecia areata and alopecia totalis. Topical immunotherapy using diphenylcyclopropenone may also be an effective treatment option for recalcitrant warts. It is not approved by either the Food and Drug Administration or the European Medicines Agency.

Chemical data

Formula
C15H10O
Molecular weight
206.24 g/mol
IUPAC name
2,3-diphenylcycloprop-2-en-1-one
SMILES
C1=CC=C(C=C1)C2=C(C2=O)C3=CC=CC=C3
InChIKey
HCIBTBXNLVOFER-UHFFFAOYSA-N
XLogP
3.3
Polar surface area
17.1 Ų
H-bond donors
0
H-bond acceptors
1
Formal charge
0

via PubChem

Drug data · ChEMBL

Max clinical phase
Phase 1
Molecule type
Small molecule
Indications
allergic disease

via ChEMBL · EBI

Wikidata facts

Mass
206.073
Show 3 more facts
chemical formula
C₁₅H₁₀O
canonical SMILES
C1=CC=C(C=C1)C2=C(C2=O)C3=CC=CC=C3
melting point
120
Sources (2)

via Wikidata · CC0

~4 min read

Encyclopedic overview

5 sections
Contents
  • Mechanism of action
  • Studies
  • Chemical properties
  • See also
  • References

Diphenylcyclopropenone (diphencyprone) is a topically administered experimental drug intended for treating alopecia areata and alopecia totalis. Topical immunotherapy using diphenylcyclopropenone may also be an effective treatment option for recalcitrant warts. It is not approved by either the Food and Drug Administration or the European Medicines Agency.

==Mechanism of action== Diphenylcyclopropenone triggers an immune response that is thought to oppose the action of the autoreactive cells that otherwise cause hair loss. One hypothesis is that in response to DPCP treatment, the body will attempt to downregulate inflammation through a variety of pathways, resulting in a downregulation of the autoimmune response at the hair follicle. This autoinflammatory reaction would otherwise destroy body's hair follicles.

Excerpted from Wikipedia’s “diphencyprone” article, available under the CC BY-SA 4.0 licence.