diphenidol
Sign in to saveAlso known as K-478-A, SK&F-478-J, SK&F-478A, SK-478, Vontrol®, alpha,alpha-Diphenyl-1-piperidinebutanol, Diphenyl(3-(1-piperidyl)propyl)carbinol, Difenidol
Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada.
Research
108 papers- Diphenidol poisoning in forensic practice: Characteristic, Mechanism, Pathologic changes and organ distribution.Legal medicine (Tokyo, Japan) · 2025
- Diphenidol treatment of arrhythmias.Chest · 1975
- Diphenidol (Vontrol).The Medical letter on drugs and therapeutics · 1967
- Retrospective Analysis of Death Cases of Oral Diphenidol Hydrochloride Poisoning.Fa yi xue za zhi · 2023
- Investigation of biodistribution by liquid-phase microextraction: Using a fatal diphenidol poisoning case.Journal of chromatography. A · 2024
via PubMed
Wikidata facts
- Mass
- 309.209264
Show 3 more facts
- chemical formula
- C₂₁H₂₇NO
- canonical SMILES
- C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
- World Health Organisation international non-proprietary name
- difenidol
via Wikidata · CC0
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Article
2 sectionsContents
- Synthesis
- References
Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada.
Although the mechanism of action of diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. A series of selective mACh-receptor antagonists based on the diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials. ==Synthesis== thumb|center|500px|Synthesis: 10%: Patents: Alkylation of 1-Bromo-3-chloropropane [109-70-6] (1) with piperidine (2) gives 3-Piperidinopropyl chloride [1458-63-5] (3). The Grignard reaction of this intermediate with benzophenone [119-61-9] gives the benzhydrol and hence, Diphenidol (4). == References ==