elobixibat

Also known as AZD7806

Elobixibat is an inhibitor of the ileal bile acid transporter (IBAT), undergoing development in clinical trials for the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C).

In the Vinony graph

Within Vinony's link graph, elobixibat is referenced by 3 other articles, and connects out to digital object identifier, chemical formula and constipation.

It is catalogued under topics including Drugs with no legal status and Laxatives.

Its subject is documented across 5 Wikipedia language editions.

Chemical data

Formula: C36H45N3O7S2
Molecular weight: 695.9 g/mol
IUPAC name: 2-[[(2R)-2-[[2-[(3,3-dibutyl-7-methylsulfanyl-1,1-dioxo-5-phenyl-2,4-dihydro-1lambda6,5-benzothiazepin-8-yl)oxy]acetyl]amino]-2-phenylacetyl]amino]acetic acid
SMILES: CCCCC1(CN(C2=CC(=C(C=C2S(=O)(=O)C1)OCC(=O)N[C@H](C3=CC=CC=C3)C(=O)NCC(=O)O)SC)C4=CC=CC=C4)CCCC
InChIKey: XFLQIRAKKLNXRQ-UUWRZZSWSA-N
XLogP: 7.1
Polar surface area: 176 Å²
H-bond donors: 3
H-bond acceptors: 9
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: Constipation, Disorder of lipid metabolism, non-alcoholic steatohepatitis

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 695.27

Show 3 more facts

chemical formula: C₃₆H₄₅N₃O₇S₂
canonical SMILES: CCCCC1(CN(C2=CC(=C(C=C2S(=O)(=O)C1)OCC(=O)NC(C3=CC=CC=C3)C(=O)NCC(=O)O)SC)C4=CC=CC=C4)CCCC
isomeric SMILES: CCCCC1(CN(C2=CC(=C(C=C2S(=O)(=O)C1)OCC(=O)N[C@H](C3=CC=CC=C3)C(=O)NCC(=O)O)SC)C4=CC=CC=C4)CCCC

Sources (2)

via Wikidata · CC0

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