Ewing sarcoma
Sign in to saveAlso known as Ewing's family localized tumor, Ewing's sarcoma/peripheral primitive neuroectodermal tumor, Ewing's tumor, Ewings sarcoma, Ewings sarcoma-primitive neuroectodermal tumor, PNET of Thoracopulmonary Region, localized Ewing sarcoma, localized Ewing's sarcoma
bone cancer that has material basis in neural crest cells derives from undeveloped, undifferentiated neuroectoderm
Key facts
- Other names
- Ewing's sarcoma Peripheral primitive neuroectodermal tumor and Askin tumor (not recommended) Ewing sarcoma family of tumors
- Pronunciation
- / ˈ juː ɪ ŋ / YOO -ing
- Specialty
- Oncology
- Symptoms
- Swell and pain near the tumor
- Complications
- Pleural effusion , paraplegia
- Usual onset
- 10 to 20 years old
- Causes
- Unknown
- Diagnostic method
- Tissue biopsy
- Differential diagnosis
- Osteosarcoma , neuroblastoma , osteomyelitis , eosinophilic granuloma
- Treatment
- Chemotherapy , radiation therapy , surgery, stem cell transplant
- Prognosis
- Five-year survival ~ 70%
- Frequency
- 1 per 1 million people (US)
via Wikipedia infobox
Research
13,229 papers- Review: Ewing Sarcoma Predisposition.Pathology oncology research : POR · 2020
- Ewing sarcoma.Seminars in diagnostic pathology · 2014
- Ewing sarcoma and Ewing-like tumors.Virchows Archiv : an international journal of pathology · 2020
- Updates on WHO classification for small round cell tumors: Ewing sarcoma vs. everything else.Human pathology · 2024
- Ewing Sarcoma, Desmoplastic Small Round Cell Tumor, and Other Round Cell Sarcomas.Hematology/oncology clinics of North America · 2025
via PubMed
Wikidata facts
- Image
- Ewing sarcoma tibia child.jpg
Show 4 more facts
- Commons category
- Ewing's sarcoma
- ICPC 2 ID
- L71
- NCI Thesaurus ID
- C27291
- exact match
- purl.obolibrary.org/obo/HP_0012254
via Wikidata · CC0
~16 min read
Article
Ewing sarcoma is a type of pediatric cancer that forms in bone or soft tissue. Symptoms may include swelling and pain at the site of the tumor, fever, and a bone fracture. The most common areas where it begins are the legs, pelvis, and chest wall. In about 25% of cases, the cancer has already spread to other parts of the body at the time of diagnosis. Complications may include a pleural effusion or paraplegia.
It is a type of small round cell sarcoma. The cause of Ewing sarcoma is unknown, most cases appearing to occur randomly. Though not strongly associated with known hereditary cancer syndromes, accumulating evidence suggests a strong inherited risk factor, identifying a genetic component having multiple chromosome loci associated with Ewing sarcoma susceptibility. Sometimes Ewing sarcoma is associated with a germline mutation. The underlying mechanism often involves a genetic change known as a reciprocal translocation. Diagnosis is based on biopsy of the tumor.