ferritin complex
Sign in to saveAlso known as ferritin, GO:0070288, ferritins
Ferritin is a universal intracellular and extracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency and iron overload.
Key facts
- Protein family.Symbol
- Ferritin
- Protein family.Name
- Ferritin
- Protein family.image
- Ferritin.png
- Protein family.caption
- Structure of the murine ferritin complex
- Protein family.Pfam
- PF00210
- Protein family.Pfam_clan
- CL0044
- Protein family.InterPro
- IPR008331
- Protein family.SCOP
- 1fha
- Protein.Name
- ferritin mitochondrial
- Protein.HGNCid
- 17345
- Protein.Symbol
- FTMT
- Protein.EntrezGene
- 94033
- Protein.OMIM
- 608847
- Protein.RefSeq
- NM_177478
- Protein.UniProt
- Q8N4E7
- Protein.Chromosome
- 5
- Protein.Arm
- q
- Protein.Band
- 23.1
via Wikipedia infobox
Research
3,347 papers- Newly uncovered biochemical and functional aspects of ferritin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
- Ferritin Complex Vaccine against Porcine Epidemic Diarrhea Virus (PEDV) Using Screened Immunogenic Sequences from Fv-Antibody Library.ACS biomaterials science & engineering · 2025
- Nuclear ferritin: a ferritoid-ferritin complex in corneal epithelial cells.Investigative ophthalmology & visual science · 2009
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.Nature · 2014
- Complex I, iron, and ferritin in Parkinson's disease substantia nigra.Annals of neurology · 1994
via PubMed
Wikidata facts
- Image
- Ferritin.png
Show 4 more facts
- exact match
- purl.obolibrary.org/obo/GO_0070288
- EC enzyme number
- 1.16.3.1
- Commons category
- Ferritin
via Wikidata · CC0
~18 min read
Article
20 sectionsContents
- Gene
- Protein structure
- Function
- Iron storage
- Ferroxidase activity
- Immune response
- Stress response
- Mitochondria
- Yolk
- Tissue distribution
- Diagnostic uses
- Normal ranges
- Deficiency
- Excess
- In chronic liver diseases
- Discovery
- Applications
- See also
- References
- External links
Ferritin is a universal intracellular and extracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency and iron overload.
Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia and iron overload. Aggregated ferritin transforms into a water-insoluble, crystalline and amorphous form of storage iron called hemosiderin.