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EntityQ412234· pop 28· linked from 125 articles

The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members include myoglobin and hemoglobin. Both of these proteins reversibly bind oxygen via a heme prosthetic group. They are widely distributed in many organisms.

Key facts

Protein family.Symbol
Protoglobin
Protein family.Name
Protoglobin (family S)
Protein family.image
PDB 1s56 EBI.jpg
Protein family.caption
crystal structure of "truncated" hemoglobin n (hbn) from mycobacterium tuberculosis, soaked with xe atoms
Protein family.Pfam
PF11563
Protein family.Pfam_clan
CL0090
Protein family.ECOD
106.1.1
Protein family.InterPro
IPR012102
Protein family.PROSITE
PDOC00933
Protein family.SCOP
1dlw
Protein family.CDD
cd01068

via Wikipedia infobox

Wikidata facts

Image
PDB 1hba EBI.jpg
Show 1 more fact
Commons category
Globins
Sources (2)

via Wikidata · CC0

~7 min read

Article

9 sections
Contents
  • Structure
  • Helix packaging
  • Evolution
  • Sequence conservation
  • Subfamilies
  • Examples
  • The globin fold
  • See also
  • References

The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members include myoglobin and hemoglobin. Both of these proteins reversibly bind oxygen via a heme prosthetic group. They are widely distributed in many organisms.

== Structure == Globin superfamily members share a common three-dimensional fold. This 'globin fold' typically consists of eight alpha helices, although some proteins have additional helix extensions at their termini. Since the globin fold contains only helices, it is classified as an all-alpha protein fold.

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