globin
Sign in to saveThe globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members include myoglobin and hemoglobin. Both of these proteins reversibly bind oxygen via a heme prosthetic group. They are widely distributed in many organisms.
Key facts
- Protein family.Symbol
- Protoglobin
- Protein family.Name
- Protoglobin (family S)
- Protein family.image
- PDB 1s56 EBI.jpg
- Protein family.caption
- crystal structure of "truncated" hemoglobin n (hbn) from mycobacterium tuberculosis, soaked with xe atoms
- Protein family.Pfam
- PF11563
- Protein family.Pfam_clan
- CL0090
- Protein family.ECOD
- 106.1.1
- Protein family.InterPro
- IPR012102
- Protein family.PROSITE
- PDOC00933
- Protein family.SCOP
- 1dlw
- Protein family.CDD
- cd01068
via Wikipedia infobox
Research
176,405 papers- Globin phylogeny, evolution and function, the newest update.Proteins · 2024
- Mechanisms of Globin Gene Regulation in Mammals.Annual review of genetics · 2025
- Globin genes on the move.Journal of biology · 2008
- Segregation of α- and β-Globin Gene Cluster in Vertebrate Evolution: Chance or Necessity?Biochemistry. Biokhimiia · 2022
- Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.Redox biology · 2020
via PubMed
Wikidata facts
- Image
- PDB 1hba EBI.jpg
Show 1 more fact
- Commons category
- Globins
Sources (2)
via Wikidata · CC0
~7 min read
Article
9 sectionsContents
- Structure
- Helix packaging
- Evolution
- Sequence conservation
- Subfamilies
- Examples
- The globin fold
- See also
- References
The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members include myoglobin and hemoglobin. Both of these proteins reversibly bind oxygen via a heme prosthetic group. They are widely distributed in many organisms.
== Structure == Globin superfamily members share a common three-dimensional fold. This 'globin fold' typically consists of eight alpha helices, although some proteins have additional helix extensions at their termini. Since the globin fold contains only helices, it is classified as an all-alpha protein fold.