guanfacine

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 461124228
Drug.image: Guanfacine.svg
Drug.image_class: skin-invert-image
Drug.image2: Guanfacine 3d ball stick.png
Drug.image_class2: bg-transparent
Drug.width2: 270
Drug.tradename: Intuniv, others
Drug.MedlinePlus: a601059
Drug.DailyMedID: Guanfacine
Drug.routes_of_administration: By mouth
Drug.class: α2A-adrenergic receptor agonist
Drug.ATC_prefix: C02
Drug.ATC_suffix: AC02
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only

via Wikipedia infobox

Chemical data

Formula: C9H9Cl2N3O
Molecular weight: 246.09 g/mol
IUPAC name: N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
InChIKey: INJOMKTZOLKMBF-UHFFFAOYSA-N
XLogP: 2
Polar surface area: 81.5 Å²
H-bond donors: 2
H-bond acceptors: 1
Formal charge: 0

via PubChem

~13 min read

Encyclopedic overview

13 sections

Contents

Medical uses
Adverse effects
Interactions
Pharmacology
Pharmacodynamics
Pharmacokinetics
Preparation
History
Society and culture
Legal status
Brand names
Research
References

Guanfacine, sold under the brand name Tenex (immediate-release) and Intuniv (extended-release) among others, is an oral alpha-2a agonist medication used to treat attention deficit hyperactivity disorder (ADHD) and high blood pressure.

Common side effects include sleepiness, constipation, and dry mouth. Other side effects may include low blood pressure and urinary problems. It appears to work by activating α2A-adrenergic receptors in the brain, thereby decreasing sympathetic nervous system activity.

Excerpted from Wikipedia’s “guanfacine” article, available under the CC BY-SA 4.0 licence.