Structure via PubChem · Public domain (PubChem)
halicin
Sign in to saveAlso known as SU-3327, SU 3327
Halicin (SU-3327) is an experimental drug that acts as an enzyme inhibitor of c-Jun N-terminal kinase (JNK). Originally, it was researched for the treatment of diabetes, but development was discontinued for this application due to poor results in testing. In 2019, this molecule was found by an artificial intelligence (AI) model to show antibiotic properties against a number of bacteria.
Chemical data
- Formula
- C5H3N5O2S3
- Molecular weight
- 261.3 g/mol
- IUPAC name
- 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine
- SMILES
- C1=C(SC(=N1)SC2=NN=C(S2)N)[N+](=O)[O-]
- InChIKey
- NQQBNZBOOHHVQP-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 192 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 260.944887336
- Has use
- medication
Show 5 more facts
- Commons category
- Halicin
- chemical formula
- C₅H₃N₅O₂S₃
- canonical SMILES
- C1=C(SC(=N1)SC2=NN=C(S2)N)[N+](=O)[O-]
- subject has role
- broad-spectrum antibiotic
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- History
- Antibiotic properties
- References
- External links
Halicin (SU-3327) is an experimental drug that acts as an enzyme inhibitor of c-Jun N-terminal kinase (JNK). Originally, it was researched for the treatment of diabetes, but development was discontinued for this application due to poor results in testing. In 2019, this molecule was found by an artificial intelligence (AI) model to show antibiotic properties against a number of bacteria.
==History== Halicin was previously known as SU-3327, developed by a group of researchers from Burnham Institute for Medical Research, United States in 2009 for investigations into diabetes treatment. Researchers named the molecule after the fictional artificial intelligence system Hal from 2001: A Space Odyssey.
Excerpted from Wikipedia’s “halicin” article, available under the CC BY-SA 4.0 licence.