Herbimycin
Sign in to saveAlso known as [(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Research
1,642 papers- New insight into oncoprotein-targeted antitumor effect: herbimycin A as an antagonist of protein tyrosine kinase against Ph1-positive leukemia cells.Leukemia & lymphoma · 1993
- Cellular and molecular characterization of the scurfy mouse mutant.Journal of immunology (Baltimore, Md. : 1950) · 1999
- Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases.The Journal of biological chemistry · 1995
- Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.Molecular pharmacology · 2004
- [Protein tyrosine kinase inhibitor, herbimycin A].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme · 1993
via PubMed
Wikidata facts
- Mass
- 574.289030924
Show 5 more facts
- chemical formula
- C₃₀H₄₂N₂O₉
- subject has role
- enzyme inhibitor
- found in taxon
- Streptomyces hygroscopicus
- isomeric SMILES
- C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)\C)C)OC)OC
- canonical SMILES
- COC1C=CC=C(C)C(=O)NC2=CC(=O)C=C(C2=O)C(OC)C(C)CC(OC)C(OC)C(C)C=C(C)C1OC(N)=O
Sources (2)
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Encyclopedic overview
5 sectionsContents
- Synonyms
- Biological activity
- See also
- References
- External links
Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
It was originally found by its herbicidal activity, and thus named. The most recent herbimycins to be discovered, herbimycins D-F, were isolated from a Streptomyces isolated from thermal vents associated with the Ruth Mullins coal fire in Appalachian Kentucky.
Excerpted from Wikipedia’s “Herbimycin” article, available under the CC BY-SA 4.0 licence.