Structure via PubChem · Public domain (PubChem)
Chemical data
- Formula
- C29H32N4O3S
- Molecular weight
- 516.7 g/mol
- IUPAC name
- N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide
- SMILES
- CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5
- InChIKey
- GLDSKRNGVVYJAB-DQSJHHFOSA-N
- XLogP
- 4.2
- Polar surface area
- 98.9 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
74 papers- Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth.Circulation · 2022
- Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations.Oncogene · 2022
- [Effect and molecular mechanism of hesperadin-induced ferroptosis in chronic myeloid leukemia K562 cells].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024
- Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases.Communications biology · 2020
- MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4/AKT Pathway in Intracerebral Hemorrhage Mice.Behavioural neurology · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 516.219512
Show 4 more facts
- chemical formula
- C₂₉H₃₂N₄O₃S
- canonical SMILES
- CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5
- isomeric SMILES
- CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5
- subject has role
- protein kinase inhibitors
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 443873334 | ImageFile = hesperadin.svg | ImageClass = skin-invert-image | ImageSize=200px | PIN=N-[(3Z)-2-Oxo-3-(phenyl{4-[(piperidin-1-yl)methyl]anilino}methylidene)-2,3-dihydro-1H-indol-5-yl]ethanesulfonamide | OtherNames= |Section1= |Section2= |Section3= }}
Hesperadin is an aurora kinase inhibitor.
Excerpted from Wikipedia’s “hesperadin” article, available under the CC BY-SA 4.0 licence.