holothurin
Sign in to saveThe holothurins are a group of toxins originally isolated from the sea cucumber Actinopyga agassizii. They are contained within clusters of sticky threads called Cuvierian tubules which are expelled from the sea cucumber as a mode of self-defence. The holothurins belong to the class of compounds known as saponins and are anionic surfactants which can cause red blood cells to rupture. The holothurins can be toxic to humans if ingested in high amounts.
Research
101 papers- Holothurin A Inhibits RUNX1-Enhanced EMT in Metastasis Prostate Cancer via the Akt/JNK and P38 MAPK Signaling Pathway.Marine drugs · 2023
- The Effects of Holothurin and Caspofungin on the Vaginal Cell Inflammation Parameters of the Rattus norvegicus Strain Post Induction of Candida albicans.Infection and drug resistance · 2023
- In vitro and in silico studies of holothurin A on androgen receptor in prostate cancer.Journal of biomolecular structure & dynamics · 2022
- Comparative study of holothurin A and echinoside A on inhibiting the high bone turnover via downregulating PI3K/AKT/β-catenin and OPG/RANKL/NF-κB signaling in ovariectomized mice.Food & function · 2022
- Function of Thelenota ananas saponin desulfated holothurin A in modulating cholesterol metabolism.Scientific reports · 2018
via PubMed
~2 min read
Article
5 sectionsContents
- Pharmacology
- Effects on nerves
- Other effects
- References
- Further reading
The holothurins are a group of toxins originally isolated from the sea cucumber Actinopyga agassizii. They are contained within clusters of sticky threads called Cuvierian tubules which are expelled from the sea cucumber as a mode of self-defence. The holothurins belong to the class of compounds known as saponins and are anionic surfactants which can cause red blood cells to rupture. The holothurins can be toxic to humans if ingested in high amounts.
==Pharmacology== ===Effects on nerves=== Holothurin is shown to have a blocking effect on nerves in desheathed bullfrog sciatic nerve and rat phrenic nerve preparations, and its potency can be compared to that of cocaine, procaine, and physostigmine. Unlike the other mentioned blocking agents, the disrupting effect of holothurin appears to be quite irreversible upon washing.