hyperalgesia
Sign in to saveHyperalgesia ( or ; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus. Prostaglandins E and F are largely responsible for sensitizing the nociceptors. Temporary increased sensitivity to pain also occurs as part of sickness behavior, the evolved response to infection.
Key facts
- Medical condition.name
- Hyperalgesia
- Medical condition.image
- Hyperalgesia and allodynia.svg
via Wikipedia infobox
Research
24,295 papers- Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms.The Lancet. Neurology · 2014
- Perioperative Hyperalgesia and Associated Clinical Factors.Current pain and headache reports · 2017
- Postoperative hyperalgesia-A clinically applicable narrative review.Pharmacological research · 2017
- Opioid-induced hyperalgesia.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2012
- Hyperalgesia, allodynia, and eventual overdose: The problems with chronic opioid use.Journal of opioid management · 2025
via PubMed
Wikidata facts
Show 3 more facts
- Commons category
- Hyperalgesia
- NCI Thesaurus ID
- C34703
- exact match
- purl.obolibrary.org/obo/SYMP_0000836
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Types
- Causes
- Medical associations
- Treatment
- See also
- References
- External links
Hyperalgesia ( or ; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus. Prostaglandins E and F are largely responsible for sensitizing the nociceptors. Temporary increased sensitivity to pain also occurs as part of sickness behavior, the evolved response to infection.
==Types== Hyperalgesia can be experienced in focal, discrete areas or as a more diffuse, body-wide form. Conditioning studies have established that it is possible to experience a learned hyperalgesia of the latter, diffuse form.