KLHDC3

Also known as PEAS, dJ20C7.3, kelch domain containing 3

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.

Gene data

KLHDC3

Name: kelch domain containing 3
Type: protein-coding
Position: 43,014,103–43,021,298 (+)
Aliases: PEAS, dJ20C7.3
Ensembl: ENSG00000124702
RefSeq RNA: NM_001242872.1, NM_057161.4, NR_040101.2, XM_047418163.1, XM_047418164.1
RefSeq protein: NP_476502.1, XP_047274119.1, XP_047274120.1, XP_054210163.1, XP_054210164.1

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012].

Gene Ontology

Biological process

reciprocal meiotic recombination protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Molecular function

chromatin binding chromatin binding chromatin binding protein binding ubiquitin-like ligase-substrate adaptor activity

Cellular component

chromatin chromatin nucleoplasm cytoplasm cytoplasm cytoplasm cytosol Cul2-RING ubiquitin ligase complex

Pathways

Cellular responses to stress XBP1(S) activates chaperone genes IRE1alpha activates chaperones Unfolded Protein Response (UPR)Cellular responses to stimuli

via MyGene.info

Gene · Ensembl

kelch domain containing 3

Symbol: KLHDC3
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:43,014,103-43,021,314
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 14290
exact match: identifiers.org/ncbigene/116138
genomic end: 42989036
genomic start: 42981951
cytogenetic location: 6p21.1

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Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.