Leptomycin

Leptomycins are secondary metabolites produced by Streptomyces spp.

Research

1,184 papers

Leptomycin B inhibits the proliferation, migration, and invasion of cultured gastric carcinoma cells.Bioscience, biotechnology, and biochemistry · 2020
Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export.Annals of the New York Academy of Sciences · 1999
Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).Biochemical and biophysical research communications · 2017
[Leptomycin: a specific inhibitor of protein nuclear export].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme · 1999
Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome.International journal of oncology · 2009

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Wikidata facts

Mass: 540.3450892559999

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chemical formula: C₃₃H₄₈O₆
isomeric SMILES: CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
canonical SMILES: O=C(O)C=C(C)CC(C)C(O)C(C(=O)C(C=C(C=CCC(C=C(C=CC1OC(=O)C=CC1C)CC)C)C)C)C

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Leptomycins are secondary metabolites produced by Streptomyces spp.

Leptomycin B (LMB) was originally discovered as a potent antifungal compound. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin. However, recent data shows that leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors in combination therapy.