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lipases

File:Lipase_PLRP2.png · Wikimedia Commons · See Wikimedia Commons

EntityQ380967· pop 46· linked from 764 articles

Also known as lipase

Lipase is a class of enzymes that catalyzes the hydrolysis of fats. Some lipases display broad substrate scope including esters of cholesterol, phospholipids, and of lipid-soluble vitamins and sphingomyelinases; however, these are usually treated separately from "conventional" lipases. Unlike esterases, which function in water, lipases "are activated only when adsorbed to an oil–water interface". Lipases perform essential roles in digestion, transport and processing of dietary lipids in most, if not all, organisms.

Key facts

Diagnostic.name
Lipase
Diagnostic.image
Lipase PLRP2.png
Diagnostic.caption
A computer-generated image of a type of pancreatic lipase (PLRP2) from the guinea pig.
Diagnostic.test of
Pancreatitis

via Wikipedia infobox

Research

57,992 papers

via PubMed

Wikidata facts

Image
Triacilglicerol lipasa.jpg
Show 2 more facts
Commons category
Lipase
EC enzyme number
3.1.1.-
Sources (3)

via Wikidata · CC0

~7 min read

Encyclopedic overview

8 sections
Contents
  • Structure and catalytic mechanism
  • Physiological distribution
  • Human lipases
  • Uses
  • Biomedicine
  • See also
  • References
  • External links

Lipase is a class of enzymes that catalyzes the hydrolysis of fats. Some lipases display broad substrate scope including esters of cholesterol, phospholipids, and of lipid-soluble vitamins and sphingomyelinases; however, these are usually treated separately from "conventional" lipases. Unlike esterases, which function in water, lipases "are activated only when adsorbed to an oil–water interface". Lipases perform essential roles in digestion, transport and processing of dietary lipids in most, if not all, organisms.

==Structure and catalytic mechanism== Classically, lipases catalyse the hydrolysis of triglycerides: \begin{align} \text{triglyceride} + \ce{H2O} &\longrightarrow \text{fatty acid} + \text{diacylglycerol} \\[4pt] \text{diacylglycerol} + \ce{H2O} &\longrightarrow \text{fatty acid} + \text{monacylglycerol} \\[4pt] \text{monacylglycerol} + \ce{H2O} &\longrightarrow \text{fatty acid} + \text{glycerol} \end{align}

Excerpted from Wikipedia’s “lipases” article, available under the CC BY-SA 4.0 licence.