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lipidomics

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thumb|400px|Examples of various lipid species.

Research

18,075 papers

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Lipids
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~15 min read

Article

15 sections
Contents
  • Structural diversity of lipids
  • Experimental techniques
  • Lipid extraction
  • Lipid separation
  • Lipid detection
  • [[Electrospray ionization|ESI MS]]
  • [[Desorption electrospray ionization|DESI MS]]
  • [[Matrix-assisted laser desorption/ionization|MALDI MS]]
  • APCI MS
  • Imaging techniques
  • Lipid profiling
  • Informatics
  • See also
  • References
  • External links

thumb|400px|Examples of various lipid species.

Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems. The word "lipidome" is used to describe the complete lipid profile within a cell, tissue, organism, or ecosystem and is a subset of the "metabolome" which also includes other major classes of biological molecules (such as amino acids, sugars, glycolysis & TCA intermediates, and nucleic acids). Lipidomics is a relatively recent research field that has been driven by rapid advances in technologies such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy, dual polarisation interferometry and computational methods, coupled with the recognition of the role of lipids in many metabolic diseases such as obesity, atherosclerosis, stroke, hypertension and diabetes. This rapidly expanding field complements the huge progress made in genomics and proteomics, all of which constitute the family of systems biology.

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