lolamicin
Sign in to saveLolamicin is an experimental antibiotic. It targets Gram-negative bacteria without significantly affecting typical gut microbes. Lolamicin was discovered by a team led by Paul J. Hergenrother at the University of Illinois Urbana-Champaign and was first reported in 2024.
Wikidata facts
Show 2 more facts
- canonical SMILES
- CC1=CC(=CC(C)=N1)C1=CNN=C1C1=CC=CC(OCC2=CC(=CC=C2)C#N)=C1
- Commons category
- Lolamicin
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- Synthesis
- References
Lolamicin is an experimental antibiotic. It targets Gram-negative bacteria without significantly affecting typical gut microbes. Lolamicin was discovered by a team led by Paul J. Hergenrother at the University of Illinois Urbana-Champaign and was first reported in 2024.
In a mouse model of bacterial infection, lolamicin was found to be especially effective against Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae.
Connections
digital object identifier
Entity
chemical formula
Entity
Escherichia coli
Entity
molar mass
Entity
Q180686
Entity
CAS Registry Number
Entity
PubChem
Entity
gram-negative bacteria
Entity
lipoprotein
Entity
simplified molecular input line entry specification
Entity
University of Illinois Urbana–Champaign
Entity
Q2311683
Entity
Klebsiella pneumoniae
Entity
nucleophilic substitution
Entity
International Chemical Identifier
Entity
standard state
Entity
Jmol
Entity
lithium diisopropylamide
Entity
Enterobacter cloacae
Entity
PyBOP
Entity