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M66 may refer to: M66 (New York City bus), a New York City Bus route in Manhattan M-66 (Michigan highway), a state highway in Michigan M66 motorway, a motorway in Greater Manchester, England Black Magic M66, the classification of a fictional android Messier 66, a spiral galaxy in the constellation Leo Mission 66, a program in the National Park Service Soltam M-66, a 160 mm mortar manufactured in Israel Smith & Wesson Model 66 (S&W M66), a variant of Smith & Wesson Model 19 (S&W M19) revolver