MACROH2A1

Name

macroH2A.1 histone

Type

protein-coding

Position

135,332,641–135,400,023 (−)

Aliases

H2A.y, H2A/y, H2AF12M, H2AFY, MACROH2A1.1, mH2A1, macroH2A1.2

Ensembl

ENSG00000113648

RefSeq RNA

NM_001040158.2, NM_001400401.1, NM_001400402.1, NM_001400403.1, NM_001400404.1

RefSeq protein

NP_001035248.1, NP_001387330.1, NP_001387331.1, NP_001387332.1, NP_001387333.1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015].

via MyGene.info

Gene · Ensembl

macroH2A.1 histone

Symbol

MACROH2A1

Biotype

Protein coding

Organism

Homo sapiens

Location

5:135,332,641-135,400,023

Strand

Reverse (−)

Assembly

GRCh38