maytansine

Also known as NSC-153858, NSC 153858

Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. The maytansine binding site and binding mode has been characterized.

Research

1,444 papers

Maytansine.Cancer treatment reviews · 1978
Biomimetic Nanoerythrosome-Coated Aptamer-DNA Tetrahedron/Maytansine Conjugates: pH-Responsive and Targeted Cytotoxicity for HER2-Positive Breast Cancer.Advanced materials (Deerfield Beach, Fla.) · 2022
New insights into the anticancer therapeutic potential of maytansine and its derivatives.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
Strategies and challenges for the next generation of antibody-drug conjugates.Nature reviews. Drug discovery · 2017
Bridging the maytansine and vinca sites: Cryptophycins target β-tubulin's T5-loop.The Journal of biological chemistry · 2024

via PubMed

Wikidata facts

Mass: 691.287

Show 6 more facts

chemical formula: C₃₄H₄₆ClN₃O₁₀
canonical SMILES: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)C)C)C)OC)(NC(=O)O2)O
found in taxon: Gymnosporia emarginata
isomeric SMILES: C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)C)C)\C)OC)(NC(=O)O2)O
World Health Organisation international non-proprietary name: maitansine
Commons category: Maitansine

Sources (2)

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