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MCAD may refer to:
==Science and technology== ACADM or MCAD, a gene Medium-chain acyl-CoA dehydrogenase, an enzyme used in lipid metabolism Medium-chain acyl-coenzyme A dehydrogenase deficiency (MCAD deficiency or MCADD), caused by mutations in the ACADM gene Mast cell activation disorder, a disease Microsoft Certified Application Developer Mechanical computer-aided design