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methylisothiazolinone
Sign in to saveAlso known as MIT, 2-Methyl-4-isothiazolin-3-one, 2-Methyl-3(2H)-isothiazolone, MI
Methylisothiazolinone (), MIT, or MI, is the organic compound with the formula S(CH)2C(O)NCH3. It is a white solid. Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications. MIT and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis.
Chemical data
- Formula
- C4H5NOS
- Molecular weight
- 115.16 g/mol
- IUPAC name
- 2-methyl-1,2-thiazol-3-one
- SMILES
- CN1C(=O)C=CS1
- InChIKey
- BEGLCMHJXHIJLR-UHFFFAOYSA-N
- XLogP
- 0
- Polar surface area
- 45.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
856 papers- Methylisothiazolinone.Dermatitis : contact, atopic, occupational, drug · 2013
- Methylisothiazolinone, quo vadis?Contact dermatitis · 2016
- Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.International journal of toxicology · 2019
- Methylisothiazolinone contact allergy: a review.The British journal of dermatology · 2011
- Methylisothiazolinone and isothiazolinone allergy.Cutis · 2019
via PubMed
~4 min read
Encyclopedic overview
6 sectionsContents
- Chemistry
- Applications
- Hazards
- Regulation
- References
- External links
Methylisothiazolinone (), MIT, or MI, is the organic compound with the formula S(CH)2C(O)NCH3. It is a white solid. Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications. MIT and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis.
== Chemistry == It is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:
Excerpted from Wikipedia’s “methylisothiazolinone” article, available under the CC BY-SA 4.0 licence.