nitrosamine

Also known as nitrosamines

thumb|150px|Structure of the nitrosamino group

Research

16,613 papers

N-Nitrosamine Formation in Pharmaceutical Solid Drug Products: Experimental Observations.Journal of pharmaceutical sciences · 2023
Nitrosamine Contamination in Pharmaceuticals: Threat, Impact, and Control.Journal of pharmaceutical sciences · 2021
N-nitrosamine Mitigation with Nitrite Scavengers in Oral Pharmaceutical Drug Products.Journal of pharmaceutical sciences · 2023
A Nitrite Excipient Database: A Useful Tool to Support N-Nitrosamine Risk Assessments for Drug Products.Journal of pharmaceutical sciences · 2023
Nitrosamine Impurities in Pharmaceuticals: An Empirical Review of their Detection, Mechanisms, and Regulatory Approaches.Current topics in medicinal chemistry · 2024

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Commons category: Nitrosamines

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Article

10 sections

Contents

Chemistry
History and occurrence
Tobacco exposure
Dietary exposure
Medication impurities
Examples
See also
Additional reading
References
External links

thumb|150px|Structure of the nitrosamino group

Nitrosamines (or more formally '''N-nitrosamines') are organic compounds produced by industrial processes. The chemical structure is , where R is usually an alkyl group. Nitrosamines have a nitroso group () that are "probable human carcinogens", bonded to a deprotonated amine. Most nitrosamines are carcinogenic in animals. A 2006 systematic review supports a "positive association between nitrite and nitrosamine intake and gastric cancer, between meat and processed meat intake and gastric cancer and oesophageal cancer, and between preserved fish, vegetable and smoked food intake and gastric cancer, but is not conclusive".