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nitroxinil
Sign in to saveNitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle. The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract. Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles.
Chemical data
- Formula
- C7H3IN2O3
- Molecular weight
- 290.01 g/mol
- IUPAC name
- 4-hydroxy-3-iodo-5-nitrobenzonitrile
- SMILES
- C1=C(C=C(C(=C1[N+](=O)[O-])O)I)C#N
- InChIKey
- SGKGVABHDAQAJO-UHFFFAOYSA-N
- XLogP
- 2.3
- Polar surface area
- 89.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 289.919
Show 3 more facts
- chemical formula
- C₇H₃IN₂O₃
- canonical SMILES
- C1=C(C=C(C(=C1[N+](=O)[O-])O)I)C#N
- Commons category
- Nitroxinil
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Nitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle. The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract. Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles.
Nitroxinil was invented by May & Baker in the mid 1960s as part of a program into investigation of derivatives of p-hydroxybenzonitrile. In addition to Nitroxynil, the herbicides ioxynil (3,5-diiodo) and bromoxynil (3,5-dibromo) were also invented by the same company. Nitroxynil has a nitro group in addition to a single iodine group.
Excerpted from Wikipedia’s “nitroxinil” article, available under the CC BY-SA 4.0 licence.