English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18027060· pop 5· linked from 5 articles

ONECUT1

Sign in to save

Also known as HNF-6, HNF6, HNF6A, one cut homeobox 1

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene.

Gene data

ONECUT1

Name: one cut homeobox 1
Type: protein-coding
Position: 52,755,053–52,791,078 (−)
Aliases: HNF-6, HNF6, HNF6A
Ensembl: ENSG00000169856
RefSeq RNA: NM_004498.4, NR_073510.2
RefSeq protein: NP_004489.1

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding chromatin binding DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleoplasm

Pathways

Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Maturity onset diabetes of the young - Homo sapiens (human)Developmental Biology Developmental Biology Regulation of beta-cell development Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Pancreatic Acinar Cells

via MyGene.info

Gene · Ensembl

one cut homeobox 1

Symbol: ONECUT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:52,755,053-52,791,078
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene.

==Function==

Excerpted from Wikipedia’s “ONECUT1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0