Structure via PubChem · Public domain (PubChem)
ارترونل
Sign in to saveAlso known as 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide, TAK-700, TAK700
Orteronel (TAK-700) is a nonsteroidal CYP17A1 inhibitor that was being developed for the treatment of cancer by Takeda Pharmaceutical Company in conjunction with Millennium Pharmaceuticals. It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result.
Chemical data
- Formula
- C18H17N3O2
- Molecular weight
- 307.3 g/mol
- IUPAC name
- 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide
- SMILES
- CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O
- InChIKey
- OZPFIJIOIVJZMN-UHFFFAOYSA-N
- XLogP
- 1.3
- Polar surface area
- 67.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 307.132
Show 2 more facts
- chemical formula
- C₁₈H₁₇N₃O₂
- canonical SMILES
- CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O
Sources (1)
via Wikidata · CC0