osteosclerosis

Osteosclerosis is a disorder characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone. Plain radiographs are a valuable tool for detecting and classifying osteosclerotic disorders. It can manifest in localized or generalized osteosclerosis. Localized osteosclerosis can be caused by Legg–Calvé–Perthes disease, sickle-cell disease and osteoarthritis among others. Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary.

==Types== ===Acquired osteosclerosis=== Osteogenic bone metastasis caused by carcinoma of prostate and breast Paget's disease of bone Myelofibrosis (primary disorder or secondary to intoxication or malignancy) Osteosclerosing types of chronic osteomyelitis Hypervitaminosis D Hyperparathyroidism Schnitzler syndrome Mastocytosis Skeletal fluorosis Monoclonal IgM Kappa cryoglobulinemia Hepatitis C.