Structure via PubChem · Public domain (PubChem)
palauamine
Sign in to save'''Palau'amine' is a toxic chlorinated alkaloid compound synthesized naturally by certain species of sea sponges. The name of the molecule derives from the island nation of Palau, near where the first sponge species discovered to produce it, Stylotella agminata, is found. It has since been isolated in other sponges, including Stylissa massa''.
Chemical data
- Formula
- C17H22ClN9O2
- Molecular weight
- 419.9 g/mol
- IUPAC name
- (1'R,4S,5R,5'R,14'S,15'S,16'S,18'S)-2,3'-diamino-15'-(aminomethyl)-16'-chloro-4-hydroxyspiro[1,4-dihydroimidazole-5,17'-2,4,6,12-tetrazapentacyclo[10.6.0.01,5.06,10.014,18]octadeca-3,7,9-triene]-11'-one
- SMILES
- C1[C@@H]2[C@H]([C@@H]([C@@]3([C@H]2[C@@]45N1C(=O)C6=CC=CN6[C@@H]4N=C(N5)N)[C@@H](N=C(N3)N)O)Cl)CN
- InChIKey
- VYOQBYCIIJYKJA-VORKOXQSSA-N
- XLogP
- -3.3
- Polar surface area
- 172 Ų
- H-bond donors
- 6
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 419.158
Show 5 more facts
- chemical formula
- C₁₇H₂₂ClN₉O₂
- canonical SMILES
- C1C2C(C(C3(C2C45N1C(=O)C6=CC=CN6C4N=C(N5)N)C(N=C(N3)N)O)Cl)CN
- isomeric SMILES
- C1[C@@H]2[C@H]([C@@H]([C@@]3([C@H]2[C@@]45N1C(=O)C6=CC=CN6[C@@H]4N=C(N5)N)[C@@H](N=C(N3)N)O)Cl)CN
- found in taxon
- Hymeniacidon agminata
- Commons category
- Palau'amine
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Biomimetic synthesis
- Biological effects
- References
'''Palau'amine' is a toxic chlorinated alkaloid compound synthesized naturally by certain species of sea sponges. The name of the molecule derives from the island nation of Palau, near where the first sponge species discovered to produce it, Stylotella agminata, is found. It has since been isolated in other sponges, including Stylissa massa.
The substance was first isolated from Stylotella agminata, a sponge found in the southwest Pacific Ocean, and described in 1993. Containing nine nitrogen atoms, the molecule is considered highly complex. The precise atomic structure was pinned down in 2007, and two years later, the molecule was synthesized in the lab of Phil Baran at the Scripps Research Institute in La Jolla, California. Early efforts towards its synthesis were directed at a misassigned structure featuring a cis- rather than trans-5/5 ring fusion, an error that was made because the trans-5/5 ring system is some 6 kcal/mol less stable than the cis''-configured system.
Excerpted from Wikipedia’s “palauamine” article, available under the CC BY-SA 4.0 licence.