PI4KA
Sign in to saveAlso known as PI4K-ALPHA, PIK4CA, pi4K230, PMGYCHA, phosphatidylinositol 4-kinase alpha, SPG84, GIDID2
Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.
Gene data
PI4KA- Name
- phosphatidylinositol 4-kinase alpha
- Type
- protein-coding
- Position
- 20,707,691–20,859,417 (−)
- Aliases
- GIDID2, PI4K-ALPHA, PIK4CA, PMGYCHA, SPG84, pi4K230
- Ensembl
- ENSG00000241973
- RefSeq RNA
- NM_001362862.2, NM_001362863.2, NM_002650.2, NM_058004.4, XM_005261635.2
- RefSeq protein
- NP_001349791.1, NP_001349792.1, NP_477352.3, XP_005261692.1, XP_011528528.1
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2018].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
phosphatidylinositol 4-kinase alpha
- Symbol
- PI4KA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:20,707,691-20,859,417
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11171
- genomic start
- 21061979
- exact match
- identifiers.org/ncbigene/5297
- genomic end
- 21213705
- cytogenetic location
- 22q11.21
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.
== Function ==