Key facts
- Drug.image
- Plecanatide sequence.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Trulance, Plectide
- Drug.DailyMedID
- Plecanatide
- Drug.licence_US
- Plecanatide
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AX07
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.IUPHAR_ligand
- 9069
- Drug.CAS_number
- 467426-54-6
- Drug.PubChem
~5 min read
Article
9 sectionsContents
- Medical uses
- Dosage and administration
- Contraindications
- Pharmacology
- Structure and function
- Mechanism of action
- Pharmacokinetics and metabolism
- References
- External links
Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India). Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.
==Medical uses== As of January 2017, plecanatide is approved in the United States for the treatment of chronic idiopathic constipation in adults. later it was also approved for irritable bowel syndrome with constipation (IBS-C).