plecanatide

Also known as Trulance, SP-304

Key facts

Drug.image: Plecanatide sequence.svg
Drug.image_class: skin-invert-image
Drug.tradename: Trulance, Plectide
Drug.DailyMedID: Plecanatide
Drug.licence_US: Plecanatide
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: A06
Drug.ATC_suffix: AX07
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.IUPHAR_ligand: 9069
Drug.CAS_number: 467426-54-6
Drug.PubChem: 70693500
Drug.DrugBank: DB13170
Drug.ChemSpiderID: 28530494
Drug.UNII: 7IK8Z952OK
Drug.KEGG: D09948
Drug.ChEMBL: 2103867

via Wikipedia infobox

Chemical data

Formula: C65H104N18O26S4
Molecular weight: 1681.9 g/mol
IUPAC name: (2S)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Protein
First approval: 2017
Admin. routes: oral
Indications: Constipation, irritable bowel syndrome

via ChEMBL · EBI

Research

130 papers

Plecanatide.2006
Plecanatide.2012
Plecanatide: First Global Approval.Drugs · 2017
Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.The American journal of medicine · 2019
Plecanatide for the treatment of chronic idiopathic constipation in adult patients.Expert review of clinical pharmacology · 2019

via PubMed

Wikidata facts

Mass: 1680.625199447999

Show 5 more facts

World Health Organisation international non-proprietary name: plecanatide
isomeric SMILES: C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)N
chemical formula: C₆₅H₁₀₄N₁₈O₂₆S₄
defined daily dose: 3
canonical SMILES: CC(C)CC(NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(N)CC(N)=O)CSSCC(NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC2=O)C(=O)NC(C(C)O)C(=O)NCC(=O)N1)C(=O)O

Sources (6)

via Wikidata · CC0

~5 min read

Article

9 sections

Contents

Medical uses
Dosage and administration
Contraindications
Pharmacology
Structure and function
Mechanism of action
Pharmacokinetics and metabolism
References
External links

Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India). Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.

==Medical uses== As of January 2017, plecanatide is approved in the United States for the treatment of chronic idiopathic constipation in adults. later it was also approved for irritable bowel syndrome with constipation (IBS-C).