Structure via PubChem · Public domain (PubChem)
plecanatide
Sign in to saveAlso known as Trulance, SP-304
Key facts
- Drug.image
- Plecanatide sequence.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Trulance, Plectide
- Drug.DailyMedID
- Plecanatide
- Drug.licence_US
- Plecanatide
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AX07
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.IUPHAR_ligand
- 9069
- Drug.CAS_number
- 467426-54-6
- Drug.PubChem
- 70693500
- Drug.DrugBank
- DB13170
- Drug.ChemSpiderID
- 28530494
- Drug.UNII
- 7IK8Z952OK
- Drug.KEGG
- D09948
- Drug.ChEMBL
- 2103867
via Wikipedia infobox
Chemical data
- Formula
- C65H104N18O26S4
- Molecular weight
- 1681.9 g/mol
- IUPAC name
- (2S)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Protein
- First approval
- 2017
- Admin. routes
- oral
- Indications
- Constipation, irritable bowel syndrome
via ChEMBL · EBI
Research
130 papers- Plecanatide.2006
- Plecanatide.2012
- Plecanatide: First Global Approval.Drugs · 2017
- Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.The American journal of medicine · 2019
- Plecanatide for the treatment of chronic idiopathic constipation in adult patients.Expert review of clinical pharmacology · 2019
via PubMed
~5 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Dosage and administration
- Contraindications
- Pharmacology
- Structure and function
- Mechanism of action
- Pharmacokinetics and metabolism
- References
- External links
Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India). Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.
==Medical uses== As of January 2017, plecanatide is approved in the United States for the treatment of chronic idiopathic constipation in adults. later it was also approved for irritable bowel syndrome with constipation (IBS-C).
Excerpted from Wikipedia’s “plecanatide” article, available under the CC BY-SA 4.0 licence.